Synthesis and Biological Evaluation of Curcumin-NSAIDs Conjugates

The present research work involves the synthesis of a total four Curcumin-NSAIDs conjugates and their subsequent biological screening for Rheumatoid Arthritis, Anti-inflammatory, Anti-ulcer activities. Curcumin is phytochemical having versatile therapeutic potential. idea conjugating curcumin with various NSAIDs somewhat novel in sense that it helps obtaining target incorporating certain desired properties like enhanced bioavailability, reduction side effects also giving good potential terms determination rheumatoid arthritis, anti-inflammatory anti-ulcer activities synthesized using appropriate animal models. Additionally, studies have been done on vivo bioavailability curcumin-NSAIDs Sprague-Dawley rats antiarthritic efficacy modified streptococcal cell wall-induced arthritis model Balb/c mice to resemble human. Curcumin-NSAID shown improved stability all mentioned when compared curcumin-NSAID conjugates; they increased curcumin’s by more than five folds significantly reduced symptoms other curcumin. structural features compounds confirmed spectral analysis. Other supporting techniques employed purity aspects include Melting point determination, Thin Layer Chromatography analysis, Recrystallization. Therefore, medicinal molecules proved be creative way increase its enhance wide range pharmacological effects.